Attenuating Treatment-Related Cardiotoxicity in Women Recently Diagnosed With Breast Cancer via a Tailored Therapeutic Exercise Program: Protocol of the ATOPE Trial

Abstract Objective Therapeutic exercise is already used to ameliorate some of the side effects cancer treatment. Recent studies examined its preventive potential regarding treatment-related toxicity, which can increase risk functional decline and lead disease recurrence death. This trial will examine whether Tailored Exercise Recovery Strategies (ATOPE) program, performed before treatment, mitigate onset extent cardiotoxicity beyond that achieved when program followed during treatment in recently diagnosed breast patients. Methods The intervention has a preparatory phase plus 12 18 sessions tailored, high-intensity exercise, post-exercise recovery strategies. A total 120 women with cancer, at due anticancer awaiting surgery by chemotherapy and/or radiotherapy, be randomized either group. In feasibility study, measurements related recruitment rate, satisfaction adherence them, retention participants, safety, adverse explored. main trial, efficacy these interventions examined. major outcome cardiotoxicity, assessed echocardiographically via left ventricular ejection fraction. Other clinical, physical, anthropometric outcomes biological hormonal variables also after diagnosis, 1 year ends, 3 years ends. Conclusion Given effect on patient survival, mitigation priority, physical therapists have an important role this mitigation. If ATOPE returns better cardioprotection results, it may recommendable patients follow program. Impact highlight need for therapist from moment prevention or cancer. It could help establish adequate therapeutic dose adapted propose correct prescription according assimilation sessions.